The overall internationalization of China's scientific and technological innovation is featured with an obvious spatial distribution characteristic of "high in the southeast and low in the northwest". The level of the internationalization of scientific and technological innovation in the eastern coastal region and the Yangtze River Economic Belt is significantly higher than that in other regions. In general, Beijing, Shanghai, Jiangsu, Guangdong, and Zhejiang are at the highest echelon in the country; The central region has a strong momentum of catching up, and Hubei obviously plays a leading role; There is a certain gap between the western region and other regions, but it has also formed the characteristics of echelon development with Sichuan, Chongqing, and Shaanxi as the leaders. The report is based on the reality of innovation and development, and highlights the characteristics of openness and cooperation. It objectively reflects the current situation of China's construction of an open innovation ecosystem and the characteristics of the level of international scientific and technological exchanges and cooperation in all regions of the country. It comprehensively and intuitively presents the "map" of China’s scientific and technological opening and cooperation, which has strong practical significance and can function as a guideline.